The Report attempts to give a comprehensive survey of regional human development problems and to identify positive socio-economic policies aimed at overcoming them. In a situation, when levels of economic development of different regions are in a range from those of African countries to countries in Central Europe, the Report emphasizes the diversity of regional development priorities and opportunities for changing people’s quality of life. It also describes the most successful regional experiences with state, regional, and municipal programmes that contribute to regional and national attainment of MDGs.